At Astellas we are a progressive health partner, delivering value and outcomes where needed.
We pursue innovative science, focussing initially on the areas of greatest potential and then developing solutions where patient need is high, often in rare or under-served disease areas and in life-threatening or life-limiting diseases and conditions.
We work directly with patients, doctors and health care professionals on the front line to ensure patient and clinical needs are guiding our development activities at every stage.
Our global vision for Patient Centricity is to support the development of innovative health solutions through a deep understanding of the patient experience. At Astellas, Patient Centricity isn’t a buzzword - it’s a guiding principle for action. We believe all staff have a role to play in creating a patient-centric culture and integrating an awareness of the patient into our everyday working practices, regardless of our role, team or division.
We work closely with regulatory authorities and payers to find new ways to ensure access to new therapies. We deliver the latest insights and real-world evidence to inform the best decisions for patients and their care-givers, to ensure the medicines we develop continue to provide meaningful outcomes.
Beyond medicines, we support our stakeholder communities to drive initiatives that improve awareness, education, access and ultimately standards of care.
The Opportunity:
As the Global Translational Medicine Lead, you will lead the development and execution of the Translational Medicine strategy in the development of Astellas’ assets. You should have a record of accomplishment of developing and executing translational science/medicine programs with mechanistically grounded biomarker and patient selection strategies. The ability to work in cross-functional teams is essential to the success of this position.
Hybrid Working:
At Astellas we recognise that our employees enjoy having a balance between their professional and home lives. We are proud of our hybrid approach which empowers you to have flexibility on whether to work from home or in the office.
Key Responsibilities:
- Develops and executes translational science and biomarker development plans, defining patient selection strategies for clinical studies.
- Provides key specifics on mechanism of action, biomarker identification, and patient selection strategies while contributing to overall development strategy and trial design.
- Works with the clinical team to implement biomarker sample collection, bioanalysis, and data interpretation.
- Contributes to clinical documents, including protocols, IBs, study reports, statistical analysis plans, publications, CSRs, and biomarker sections of regulatory submissions.
- Leads reverse translation to leverage clinical results for development strategy and enhances understanding of the mechanism of action for clinical translation.
- Drives innovation by identifying and evaluating state-of-the-art technologies and establishing external collaborations focused on translational medicine.
Essential Knowledge & Experience:
- Extensive experience in drug discovery and development within biotech/pharmaceutical companies or equivalent translational research at an academic institution.
- Broad knowledge of cancer biology, cancer genomics, and oncology drug development.
- Expertise in identifying and validating pharmacodynamic and patient selection biomarkers, biomarker assay qualification, and clinical implementation.
- Proven ability to lead teams and drive high-quality, timely results through influence in a matrix environment.
- Strong technical experience with DNA, RNA, and protein-based biomarker assays (e.g., PCR, NGS, ELISA/MSD, IHC) and fit-for-purpose biomarker assay qualification/validation.
- Innovation-driven mindset with a track record of integrating new technologies into translational and biomarker research, along with strong communication, interpersonal, and leadership skills.
Preferred Experience:
- Experience in developing and managing academic collaboration and CRO work.
Education:
- Advanced science degree (PhD, PharmD, or MD) with primary focus in oncology and/or immuno-oncology or equivalent.
Additional information:
- This is a permanent, full-time position
- Position is based in the United Kingdom or in the Netherlands.
- This position follows our hybrid working model. Role requires a blend of home and a minimum of 1 day per quarter in our London or Leiden. Flexibility may be required in line with business need.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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